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Applied Physics Letters / Volume 99 / Issue 25 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 99, 253701 (2011); http://dx.doi.org/10.1063/1.3666819 (3 pages)

Dielectric barrier discharge plasma in Ar/O2 promoting apoptosis behavior in A549 cancer cells

Jun Huang1, Hui Li1, Wei Chen1, Guo-Hua Lv1, Xing-Quan Wang1, Guo-Ping Zhang1, Kostya Ostrikov2,3, Peng-Ye Wang1, and Si-Ze Yang1,4

1The Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China
2Plasma Nanoscience Centre Australia (PNCA), CSIRO Materials Science and Engineering, P.O. Box 218, Lindfield, New South Wales 2070, Australia
3School of Physics, The University of Sydney, Sydney, New South Wales 2006, Australia
4Department of Aeronautics, Fujian Key Laboratory for Plasma and Magnetic Resonance, School of Physics and Mechanical and Electrical Engineering, Xiamen University, Xiamen 361005, China

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(Received 16 October 2011; accepted 24 October 2011; published online 19 December 2011)

The Ar/O2 plasma needle in the induction of A549 cancer cells apoptosis process is studied by means of real-time observation. The entire process of programmed cell death is observed. The typical morphological changes of A549 apoptosis are detected by 4′, 6-diamidino-2-phenylindole staining, for example, chromatin condensation and nuclear fragmentation. Cell viability is determined and quantified by neutral red uptake assay, and the survival rate of A549 from Ar/O2 plasmas is presented. Further spectral analysis indicates the reactive species, including O and OH play crucial roles in the cell inactivation.

© 2011 American Institute of Physics

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KEYWORDS and PACS

Keywords

argon, biological effects of ionising radiation, cancer, cellular effects of radiation, condensation, discharges (electric), oxygen, patient treatment, plasma applications

PACS

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3666819

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

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