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Applied Physics Letters / Volume 99 / Issue 25 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 99, 253703 (2011); http://dx.doi.org/10.1063/1.3669534 (3 pages)

Room-temperature, atmospheric plasma needle reduces adenovirus gene expression in HEK 293A host cells

Z. Xiong1, X. Lu1, Y. Cao2, Q. Ning3, K. Ostrikov4, Y. Lu5, X. Zhou2, and J. Liu3

1State Key Laboratory of Advanced Electromagnetic Engneering and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of China
2Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of China
3Laboratory of Infectious Immunology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of China
4Plasma Nanoscience Centre Australia (PNCA), CSIRO Materials Science and Engineering, P. O. Box 218, Lindfield, New South Wales 2070, Australia and Complex Systems, School of Physics, The University of Sydney, Sydney, New South Wales 2006, Australia
5School of Physics, Anhui University, Hefei, Anhui 230039, People’s Republic of China

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(Received 13 November 2011; accepted 21 November 2011; published online 20 December 2011)

Room-temperature, atmospheric-pressure plasma needle treatment is used to effectively minimize the adenovirus (AdV) infectivity as quantified by the dramatic reduction of its gene expression in HEK 293A primary human embryonic kidney cells studied by green fluorescent protein imaging. The AdV titer is reduced by two orders of magnitude within only 8 min of the plasma exposure. This effect is due to longer lifetimes and higher interaction efficacy of the plasma-generated reactive species in confined space exposed to the plasma rather than thermal effects commonly utilized in pathogen inactivation. This generic approach is promising for the next-generation anti-viral treatments and imunotherapies.

© 2011 American Institute of Physics

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KEYWORDS and PACS

Keywords

biomedical optical imaging, diseases, fluorescence, genetics, kidney, microorganisms, patient treatment, plasma applications, proteins

PACS

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3669534

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    A. Shashurin, M. Keidar, S. Bronnikov, R. A. Jurjus, and M. A. Stepp, Appl. Phys. Lett. 93, 181501 (2008)APPLAB000093000018181501000001.

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    X. P. Lu, Z. Xiong, F. Zhao, Y. Xian, Q. Xiong, W. Gong, C. Zou, Z. Jiang, and Y. Pan, Appl. Phys. Lett. 95, 181501 (2009)APPLAB000095000018181501000001.

    Q. Xiong, X. P. Lu, A. Feng, Y. Pan, and K. Ostrikov, Phys Plasmas 17, 123502 (2010)PHPAEN000017000012123502000001.

    D. Mariotti, Appl. Phys. Lett. 92, 151505 (2008)APPLAB000092000015151505000001.

    X. Yan, F. Zou, and X. Lu, Appl. Phys. Lett. 95, 083702 (2009)APPLAB000095000008083702000001.


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