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Applied Physics Letters / Volume 99 / Issue 25 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 99, 253704 (2011); http://dx.doi.org/10.1063/1.3671078 (4 pages)

Solid-state sensor incorporated in microfluidic chip and magnetic-bead enzyme immobilization approach for creatinine and glucose detection in serum

Yen-Heng Lin1,2,3, Chien-Hung Chiang1, Min-Hsien Wu2,4, Tung-Ming Pan1,2, Ji-Dung Luo5, and Chiuan-Chian Chiou6

1Department of Electronic Engineering, Chang Gung University, Taoyuan 333, Taiwan
2Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
3Graduate Institute of Medical Mechatronics, Chang Gung University, Taoyuan 333, Taiwan
4Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 333, Taiwan
5Division of Biotechnology, Graduate Institute of Biomedical Science, Chang Gung University, Taoyuan 333, Taiwan
6Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan 333, Taiwan

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(Received 2 October 2011; accepted 22 November 2011; published online 21 December 2011)

Solid-state sensors are stable and inexpensive electric transducers for biomedical measurement. This study proposes a microfluidic chip incorporated with a solid-state sensor for measuring glucose and creatinine in blood serum. Magnetic beads are employed to immobilize enzymes and deliver them in a micro-channel. Glucose and creatinine can be measured at 2–8 mM and 10−2 to 10 mM, respectively, which is a meaningful range in human blood. The immobilization approach also addresses the issue of the long-term preservation of enzymes in microfluidic devices. The proposed device is suitable for multi-target measurement in a point-of-care system.

© 2011 American Institute of Physics

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KEYWORDS and PACS

Keywords

biochemistry, biomedical measurement, biomedical transducers, bioMEMS, biosensors, blood, enzymes, lab-on-a-chip, microfluidics, microsensors, molecular biophysics

PACS

  • 87.85.Ox

    Biomedical instrumentation and transducers, including micro-electro-mechanical systems (MEMS)

  • 87.14.ej

    Enzymes

  • 07.10.Cm

    Micromechanical devices and systems

  • 85.85.+j

    Micro- and nano-electromechanical systems (MEMS/NEMS) and devices

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3671078

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

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