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Applied Physics Letters / Volume 99 / Issue 25 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 99, 253705 (2011); http://dx.doi.org/10.1063/1.3669698 (3 pages)

Flow-enhanced transient response in whispering gallery mode biosensors

Jason M. Gamba and Richard C. Flagan

Department of Chemical Engineering, California Institute of Technology, 1200 E. California Boulevard, Pasadena, California 91125, USA

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(Received 1 September 2011; accepted 11 November 2011; published online 21 December 2011)

Whispering gallery mode (WGM) optical resonator sensors are an extremely sensitive label-free technology for detecting the binding of biomolecules in solution. To better understand the fast transient response observed with these devices, we model mass transfer to spherical and toroidal WGM sensors of identical outer radius. Finite element simulations predict a 3-10 fold higher binding frequency for toroidal sensors. These results agree to within an order of magnitude with experimental data from the literature and suggest a design strategy to improve the transient response of a sensor by making the device small only in the dimension that governs boundary layer development.

© 2011 American Institute of Physics

ERRATUM

  1. Erratum: “Flow-enhanced transient response in whispering gallery mode biosensors” [Appl. Phys. Lett. 99, 253705 (2011)]
    Jason M. Gamba et al.
    Appl. Phys. Lett. 100, 149901 (2012)APPLAB000100000014149901000001

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KEYWORDS and PACS

Keywords

biochemistry, biosensors, finite element analysis, mass transfer, molecular biophysics, optical resonators, optical sensors, whispering gallery modes

PACS

  • 87.80.-y

    Biophysical techniques (research methods)

  • 87.15.N-

    Properties of solutions of macromolecules

  • 42.79.-e

    Optical elements, devices, and systems

  • 07.07.Df

    Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3669698

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

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