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19 Dec 2011

Volume 99, Issue 25, Articles (25xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 99, 253701 (2011); http://dx.doi.org/10.1063/1.3666819 (3 pages)

Jun Huang, Hui Li, Wei Chen, Guo-Hua Lv, Xing-Quan Wang, Guo-Ping Zhang, Kostya Ostrikov, Peng-Ye Wang, and Si-Ze Yang
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Dielectric barrier discharge plasma in Ar/O2 promoting apoptosis behavior in A549 cancer cells

Jun Huang, Hui Li, Wei Chen, Guo-Hua Lv, Xing-Quan Wang, Guo-Ping Zhang, Kostya Ostrikov, Peng-Ye Wang, and Si-Ze Yang

Appl. Phys. Lett. 99, 253701 (2011); http://dx.doi.org/10.1063/1.3666819 (3 pages) | Cited 5 times

Online Publication Date: 19 December 2011

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The Ar/O2 plasma needle in the induction of A549 cancer cells apoptosis process is studied by means of real-time observation. The entire process of programmed cell death is observed. The typical morphological changes of A549 apoptosis are detected by 4′, 6-diamidino-2-phenylindole staining, for example, chromatin condensation and nuclear fragmentation. Cell viability is determined and quantified by neutral red uptake assay, and the survival rate of A549 from Ar/O2 plasmas is presented. Further spectral analysis indicates the reactive species, including O and OH play crucial roles in the cell inactivation.
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87.53.-j Effects of ionizing radiation on biological systems
87.17.-d Cell processes
52.77.-j Plasma applications
87.19.xj Cancer
52.80.-s Electric discharges

Characterization of a light switchable microelectrode array for retinal prosthesis

Xinyi Zhang, Tao Xiong, Pei-Yu Chiou, and Zhihong Li

Appl. Phys. Lett. 99, 253702 (2011); http://dx.doi.org/10.1063/1.3670299 (3 pages)

Online Publication Date: 19 December 2011

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A light switchable microelectrode array for retinal prosthesis, which is performed with the photosensitive conductivity of hydrogenated amorphous silicon (a-Si:H) and of more advantages over the two major current retinal prosthetic categories, is characterized. Sensitivity to different visible wavelengths and light intensities are verified as well. Preliminary impedance test invitro shows appropriate impedance for neuron stimulation applications. It is indicated that such device provides a promising potential to restore a certain degree of visual function.
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87.85.F- Smart prosthetics
42.66.-p Physiological optics

Room-temperature, atmospheric plasma needle reduces adenovirus gene expression in HEK 293A host cells

Z. Xiong, X. Lu, Y. Cao, Q. Ning, K. Ostrikov, Y. Lu, X. Zhou, and J. Liu

Appl. Phys. Lett. 99, 253703 (2011); http://dx.doi.org/10.1063/1.3669534 (3 pages) | Cited 3 times

Online Publication Date: 20 December 2011

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Room-temperature, atmospheric-pressure plasma needle treatment is used to effectively minimize the adenovirus (AdV) infectivity as quantified by the dramatic reduction of its gene expression in HEK 293A primary human embryonic kidney cells studied by green fluorescent protein imaging. The AdV titer is reduced by two orders of magnitude within only 8 min of the plasma exposure. This effect is due to longer lifetimes and higher interaction efficacy of the plasma-generated reactive species in confined space exposed to the plasma rather than thermal effects commonly utilized in pathogen inactivation. This generic approach is promising for the next-generation anti-viral treatments and imunotherapies.
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87.16.-b Subcellular structure and processes
87.17.-d Cell processes
87.14.E- Proteins
87.19.X- Diseases
87.85.-d Biomedical engineering
52.77.-j Plasma applications

Solid-state sensor incorporated in microfluidic chip and magnetic-bead enzyme immobilization approach for creatinine and glucose detection in serum

Yen-Heng Lin, Chien-Hung Chiang, Min-Hsien Wu, Tung-Ming Pan, Ji-Dung Luo, and Chiuan-Chian Chiou

Appl. Phys. Lett. 99, 253704 (2011); http://dx.doi.org/10.1063/1.3671078 (4 pages) | Cited 2 times

Online Publication Date: 21 December 2011

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Solid-state sensors are stable and inexpensive electric transducers for biomedical measurement. This study proposes a microfluidic chip incorporated with a solid-state sensor for measuring glucose and creatinine in blood serum. Magnetic beads are employed to immobilize enzymes and deliver them in a micro-channel. Glucose and creatinine can be measured at 2–8 mM and 10−2 to 10 mM, respectively, which is a meaningful range in human blood. The immobilization approach also addresses the issue of the long-term preservation of enzymes in microfluidic devices. The proposed device is suitable for multi-target measurement in a point-of-care system.
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87.85.Ox Biomedical instrumentation and transducers, including micro-electro-mechanical systems (MEMS)
87.14.ej Enzymes
07.10.Cm Micromechanical devices and systems
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices

Flow-enhanced transient response in whispering gallery mode biosensors

Jason M. Gamba and Richard C. Flagan

Appl. Phys. Lett. 99, 253705 (2011); http://dx.doi.org/10.1063/1.3669698 (3 pages) | Cited 2 times

Online Publication Date: 21 December 2011

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See Also: Erratum

Show Abstract
Whispering gallery mode (WGM) optical resonator sensors are an extremely sensitive label-free technology for detecting the binding of biomolecules in solution. To better understand the fast transient response observed with these devices, we model mass transfer to spherical and toroidal WGM sensors of identical outer radius. Finite element simulations predict a 3-10 fold higher binding frequency for toroidal sensors. These results agree to within an order of magnitude with experimental data from the literature and suggest a design strategy to improve the transient response of a sensor by making the device small only in the dimension that governs boundary layer development.
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87.80.-y Biophysical techniques (research methods)
87.15.N- Properties of solutions of macromolecules
42.79.-e Optical elements, devices, and systems
07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing
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