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Applied Physics Letters / Volume 99 / Issue 26 / NANOSCALE SCIENCE AND DESIGN

Appl. Phys. Lett. 99, 263112 (2011); http://dx.doi.org/10.1063/1.3673277 (3 pages)

Controlling the conformations and transport of DNA by free energy landscaping

Elijah Shelton, Zhijun Jiang, Shutong Wang, and Derek Stein

Department of Physics, Brown University, 02912 Providence, Rhode Island, USA

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(Received 23 August 2011; accepted 4 December 2011; published online 30 December 2011; corrected 9 January 2012)

We demonstrate free energy landscaping, a method for controlling the transport and conformations of DNA in nanofluidic devices with a nanotopography. A device that funnels molecules into traps where they adopt the shapes of letters illustrates the principle. We analyze how the nanotopography establishes regions of lower free energy and how entropic forces compete with advection, Brownian motion, and, importantly, excluded volume interactions; a rise in the density of DNA can be induced to facilitate its escape from a trap at a controlled location. An ability to guide DNA into solvent-permeable traps makes free energy landscaping applicable to genetic analyses.

© 2011 American Institute of Physics

EDITORIALLY RELATED

  1. Publisher's Note: “Controlling the conformations and transport of DNA by free energy landscaping” [Appl. Phys. Lett. 99, 263112 (2011)]
    Elijah Shelton et al.
    Appl. Phys. Lett. 100, 089901 (2012)APPLAB000100000008089901000001

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KEYWORDS and PACS

Keywords

biological techniques, biotransport, Brownian motion, DNA, free energy, genetics, molecular biophysics, molecular configurations, nanobiotechnology, nanofluidics

PACS

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3673277

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    P. Hänggi, P. Talkner, and M. Borkovec, Rev. Mod. Phys. 62, 251 (1990).


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