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1 Aug 2011

Volume 99, Issue 5, Articles (05xxxx)

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Appl. Phys. Lett. 99, 051112 (2011); http://dx.doi.org/10.1063/1.3617421 (3 pages)

Wei Li, Jun Chen, Gerard Nouet, Liang-yao Chen, and Xunya Jiang
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Pulsed electric breakdown in adipose tissue

Juergen F. Kolb, Noah Scully, and Dilip Paithankar

Appl. Phys. Lett. 99, 053701 (2011); http://dx.doi.org/10.1063/1.3619812 (3 pages)

Online Publication Date: 1 August 2011

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High voltage pulses of sub-microsecond duration can instigate electrical breakdown in adipose tissue, which is followed by a spark discharge. Breakdown voltages are generally lower than observed for purified lipids but higher than for air. Development of breakdown for the repetitive application of pulses resembles a gradual and stochastic process as reported for partial discharges in solid dielectrics. The inflicted tissue damage itself is confined to the gap between electrodes, providing a method to use spark discharges as a precise surgical technique.
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87.50.ct Therapeutic applications
87.19.rf Dielectric properties
87.85.-d Biomedical engineering
87.17.-d Cell processes

Probing the physiology of ASH neuron in Caenorhabditis elegans using electric current stimulation

Trushal Vijaykumar Chokshi, Daphne Bazopoulou, and Nikos Chronis

Appl. Phys. Lett. 99, 053702 (2011); http://dx.doi.org/10.1063/1.3615821 (3 pages) | Cited 1 time

Online Publication Date: 1 August 2011

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Electrical stimulation has been widely used to modulate and study the in vitro and in vivo functionality of the nervous system. Here, we characterized the effect of electrical stimulation on ASH neuron in Caenorhabditis elegans and employed it to probe the neuron’s age dependent properties. We utilized an automated microfluidic-based platform and characterized the ASH neuronal activity in response to an electric current applied to the worm’s body. The electrically induced ASH neuronal response was observed to be dependent on the magnitude, polarity, and spatial location of the electrical stimulus as well as on the age of the worm.
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87.19.lb Action potential propagation and axons
87.19.ld Electrodynamics in the nervous system
87.17.-d Cell processes
87.80.Ek Mechanical and micromechanical techniques
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
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