APL Nameplate
  • Volume/Page
  • Keyword
  • DOI
  • Citation
  • Advanced
   
 
 
 

Flickr Twitter iResearch App Facebook

BROWSE VOLUMES

Year Range: 
Search Issue | RSS Feeds RSS
Previous Issue Next Issue

15 Aug 2011

Volume 99, Issue 7, Articles (07xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 99, 073701 (2011); http://dx.doi.org/10.1063/1.3599706 (3 pages)

Miguel A. Santiago-Cordoba, Svetlana V. Boriskina, Frank Vollmer, and Melik C. Demirel
Enlarge Image | Read More
Return to All Sections
back to top
RSS Feeds

Nanoparticle-based protein detection by optical shift of a resonant microcavity

Miguel A. Santiago-Cordoba, Svetlana V. Boriskina, Frank Vollmer, and Melik C. Demirel

Appl. Phys. Lett. 99, 073701 (2011); http://dx.doi.org/10.1063/1.3599706 (3 pages) | Cited 23 times

Online Publication Date: 15 August 2011

Full Text: Read Online (HTML) | Download PDF

Show Abstract
We demonstrated a biosensing approach which, for the first time, combines the high sensitivity of whispering gallery modes (WGMs) with a metallic nanoparticle-based assay. We provided a computational model based on generalized Mie theory to explain the higher sensitivity of protein detection. We quantitatively analyzed the binding of a model protein (i.e., Bovine Serum Albumin) to gold nanoparticles from high-Q WGM resonance frequency shifts, and fit the results to an adsorption isotherm, which agrees with the theoretical predictions of a two-component adsorption model.
Show PACS
87.80.Dj Spectroscopies
87.14.E- Proteins
84.40.Az Waveguides, transmission lines, striplines
42.82.Et Waveguides, couplers, and arrays
42.25.Fx Diffraction and scattering

Modeling and reconstruction of optical tomography for endoscopic applications: Simulation demonstration

Xueli Chen, Jimin Liang, Heng Zhao, Xiaochao Qu, Duofang Chen, Qitan Zhang, Xinbo Gao, and Jie Tian

Appl. Phys. Lett. 99, 073702 (2011); http://dx.doi.org/10.1063/1.3626033 (3 pages) | Cited 1 time

Online Publication Date: 16 August 2011

Full Text: Read Online (HTML) | Download PDF

Show Abstract
Applications of optical tomography in noninvasive cancer imaging have been restricted to specific organs that can be measured or transilluminated externally. However, these external measurements are limited to superficial area or small animals, and inaccurate or immeasurable for imaging the internal organ deep inside the large body. Endoscopic optical tomography (EOT) overcomes this limitation and improves this inaccuracy or immeasurability by taking the detector closer to the region of interest with a minimally invasive approach. In this letter, we present an endoscopic algorithm for EOT, including establishing a realistic endoscopic geometry, constructing an accurate forward model and advancing an effective inverse reconstruction algorithm. Bioluminescent mode based simulations show the accuracy and effectiveness of the endoscopic algorithm in both localization and quantification.
Show PACS
87.63.L- Visual imaging
87.15.mq Luminescence
87.19.xj Cancer
87.57.nf Reconstruction

The application of fixed hydrophobic patterns for confinement of aqueous solutions in proteomic microarrays

Y. Li, E. O. McKenna, W. Parkes, A. R. Pitt, and A. J. Walton

Appl. Phys. Lett. 99, 073703 (2011); http://dx.doi.org/10.1063/1.3626037 (3 pages) | Cited 1 time

Online Publication Date: 18 August 2011

Full Text: Read Online (HTML) | Download PDF

Show Abstract
A protein microarray hybridisation system has been implemented by employing patterned hydrophobic thin films on hydrophilic substrates as a means of confinement for aqueous samples. This approach has the ability to handle, and keep separate, small sample volumes of just a few microlitres. In addition, the system is more straightforward to use than the existing multi-well gasket solution. The paper describes the fabrication method and the system is demonstrated for a model protein microarray assay.
Show PACS
87.80.Ek Mechanical and micromechanical techniques
87.80.Un Proteomic techniques
87.85.mk Proteomics
81.16.Rf Micro- and nanoscale pattern formation
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
87.14.E- Proteins

Backward elastic light scattering of malaria infected red blood cells

Seungjun Lee and Wei Lu

Appl. Phys. Lett. 99, 073704 (2011); http://dx.doi.org/10.1063/1.3627173 (3 pages)

Online Publication Date: 19 August 2011

Full Text: Read Online (HTML) | Download PDF

Show Abstract
We investigated the backward light scattering pattern of healthy and malaria (Plasmodium falciparum) parasitized red blood cells. The spectrum could clearly distinguish between predominant ring stage infected blood cells and healthy blood cells. Further, we found that infected samples mixed with different stages of P. falciparum showed different signals, suggesting that even variance in parasite stages could also be detected by the spectrum. These results together with the backward scattering technique suggest the potential of non-invasive diagnosis of malaria through light scattering of blood cells near the surface of human body, such as using eyes or skin surface.
Show PACS
87.64.Cc Scattering of visible, uv, and infrared radiation
87.50.wf Biophysical mechanisms of interaction
87.19.xe Parasitic diseases
Return to All Sections
Close

Google Calendar

ADVERTISEMENT

Go to AIP Home   © AIP Publishing LLC
close