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22 Aug 2011

Volume 99, Issue 8, Articles (08xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 99, 083104 (2011); http://dx.doi.org/10.1063/1.3625926 (3 pages)

E. Detsi, Z. G. Chen, W. P. Vellinga, P. R. Onck, and J. T. M. De Hosson
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Effect of loading rates on cellular force measurements by polymer micropillar based transducers

Ping Du, Xiaoyu Zheng, I-Kuan Lin, and Xin Zhang

Appl. Phys. Lett. 99, 083701 (2011); http://dx.doi.org/10.1063/1.3628456 (3 pages)

Online Publication Date: 23 August 2011

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Polymeric deformable sensor arrays have been employed to measure cellular forces and offered insights into the study of cellular mechanics. Previous studies have been focused on using transducers in static domain and assumed elastic beam theory as the force conversion model. Neglecting the inherent viscoelastic behavior of polydimethylsiloxane and low aspect ratios of the sensor arrays compromised the accuracy of these devices. In this work, a more in-depth viscoelastic Timoshenko beam model was developed incorporating dynamic cellular forces. We studied chemically stimulated contractions of cardiac myocytes and found that the loading rate has a considerable influence on the sensitivity of the sensor arrays.
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87.17.Rt Cell adhesion and cell mechanics
07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing
87.85.-d Biomedical engineering
87.85.J- Biomaterials
07.07.Mp Transducers
87.19.Ff Muscles

Biophysical characterization of hematopoietic cells from normal and leukemic sources with distinct primitiveness

Youhua Tan, Tsz-Kan Fung, Haixia Wan, Kaiqun Wang, Anskar Y. H. Leung, and Dong Sun

Appl. Phys. Lett. 99, 083702 (2011); http://dx.doi.org/10.1063/1.3610938 (3 pages) | Cited 4 times

Online Publication Date: 24 August 2011

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This letter reported the biophysical characterization of immunophenotypically distinct hematopoietic cells from normal and leukemic sources, through manipulation with optical tweezers at single cell level. The results show that the percentage of cells that are stretchable and their deformability are significantly higher in the more primitive cell populations. This study provides the evidence that normal and leukemic hematopoietic cell populations with distinct primitiveness exhibit differential biophysical properties. These findings raise a hypothesis that the high deformability may be related to the unique functions and activities of primitive hematopoietic cells.
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87.85.G- Biomechanics
87.85.Uv Micromanipulators
87.17.Rt Cell adhesion and cell mechanics
87.19.xj Cancer
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